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Thelma C. Hurd, MD; Kumar S. Dasmahapatra, MD; Benjamin F. Rush, Jr, MD; George W. Machiedo, MD

Arch Surg. 1988;123(2):217-220.

Abstract
• Red blood cell (RBC) "deformability" is necessary for maintenance of normal microcirculation. To determine whether RBC deformability was affected in human or murine sepsis, a deformability index was determined in a human study and a murine model. Deformability was decreased postoperatively in patients with sepsis (0.49 ±0.12) compared with patients without sepsis (1.62±0.13) and normal control volunteers (1.51 ±0.17). Deformability was decreased in rats that had undergone cecal ligation and puncture (0.37±0.06) compared with that of sham-operated rats (0.76 ±0.12), as well as in endotoxemic rats (0.38 ±0.4) compared with control rats (0.82 ±0.11). These data suggest that RBC deformability decreases in both human and murine sepsis. This effect could be an important factor in the disordered oxygen utilization noted in human sepsis, and its correction could lead to better tissue oxygenation and preserved organ function.

(Arch Surg 1988;123:217-220)

Author Affiliations
From the Surgical Service, Veterans Administration Medical Center, East Orange, NJ, and Department of Surgery, University of Medicine and Dentistry—New Jersey Medical School, Newark.

Footnotes
Accepted for publication Sept 9, 1987.

Read before the Seventh Annual Meeting of the Surgical Infection Society, Philadelphia, May 12, 1987.

Reprint requests to Department of Surgery, MSB G-530, University of Medicine and Dentistry—New Jersey Medical School, 185 S Orange Ave, Newark, NJ 07103 (Dr Machiedo).

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