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Generation of an Anti—Interleukin 2 Factor in Healing Wounds
Robert J. Breslin, MD;
Adrian Barbul, MD;
Thomas S. Kupper, MD;
John P. Knud-Hansen, MD;
Hannah L. Wasserkrug;
Gershon Efron, MD
Arch Surg. 1988;123(3):305-308.
Abstract
• Previously we have noted that fluid obtained from ten-day-old healing wounds noncytotoxically inhibits the blastogenesis of lymphocytes in response to mitogens or antigens. Since these lymphocytic responses are interleukin 2 (IL-2)—mediated, we looked for a specific IL-2 inhibitor in wound fluid. We have found that wound fluid blocks the response of thymic lymphocytes and of two cloned T-helper cell lines (D10 and HT2) to exogenous human recombinant IL-2. The wound fluid enhances fibroblast proliferation, thus demonstrating that its proliferative inhibitory activity is specific for lymphocytes. The findings suggest that wound fluid contains a factor that impairs lymphocyte response to IL-2, probably at the receptor or postreceptor level.
(Arch Surg 1988;123:305-308)
Author Affiliations
From the Departments of Surgery, Sinai Hospital and The Johns Hopkins University, Baltimore.
Footnotes
Accepted for publication June 29, 1987.
Read before the Seventh Annual Meeting of the Surgical Infection Society, Philadelphia, May 12, 1987.
Reprint requests to Department of Surgery, Sinai Hospital of Baltimore, 2401 W Belvedere Ave, Baltimore, MD 21215 (Dr Barbul).
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