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Effects of Muramyl Dipeptide and Core Body Temperature on Peritoneal Bacterial Clearance
Thomas A. Stellato, MD;
Michael C. Townsend, MD;
Nahida Gordon, PhD;
Larry H. Danziger, PharmD;
Pam Galloway, MD;
Natalie L. Hawkins;
Donald E. Fry, MD
Arch Surg. 1988;123(4):465-469.
Abstract
• To examine the interaction between muramyl dipeptide (MDP) and core body temperature in murine peritonitis, 120 Sprague-Dawley rats were randomized to receive either 0, 1, or 4 µg/g body weight of MDP. Twenty-four hours later a sublethal intraperitoneal inoculation of Escherichia coli was given after core body temperature regulation at 32°C to 40°C, which was maintained for 30 minutes. Killing of the rats at 1, 3, or 6 hours later allowed evaluation of peritoneal white blood cell and bacterial counts. Results demonstrated that MDP (independent of core body temperature) caused an increased peritoneal white blood cell response at one and six hours and an increased peritoneal bacterial clearance at three hours. Increasing core body temperature adversely affected peritoneal bacterial clearance. High-dose MDP was clearly significant in acceleration of peritoneal bacterial clearance. No interaction between MDP and core body temperature was seen.
(Arch Surg 1988;123:465-469)
Author Affiliations
From the Departments of Surgery (Drs Stellato, Townsend, Gordon, Danziger, and Fry and Ms Hawkins), Epidemiology and Biostatistics (Dr Gordon), and Pathology (Dr Galloway), Case Western Reserve University School of Medicine, Cleveland.
Footnotes
Accepted for publication Sept 11, 1987.
Read before the Association of Veterans Administration Surgeons, Portland, Ore, May 8, 1987.
Reprint requests to Department of Surgery, Case Western Reserve University School of Medicine, 2065 Adelbert Rd, Cleveland, OH 44106 (Dr Stellato).
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