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Steven D. Leach, MD; Allan L. Toole, MD; Harold Stern, MD; Ralph W. DeNatale, MD; M. David Tilson, MD

Arch Surg. 1988;123(5):606-609.

Abstract
• We retrospectively identified 136 patients with abdominal aortic aneurysms (AAAs) who were initially evaluated as outpatients. Twenty-seven of these patients met the following criteria for eligibility in the study: (1) roentgenographic documentation of an AAA larger than 3 cm, (2) at least two serial ultrasound size determinations over a minimum six-month interval, and (3) a documented medication history. Of these 27 patients, 12 received long-term β-blockade, while 15 received no β-blockade. The two groups were comparable with respect to age, sex, initial aneurysm size, mean systolic and diastolic blood pressure, and duration of follow-up (mean, 34 months). Among patients with β-blockade, the mean growth rate was 0.17 cm/y. The rate for the controls was 0.44 cm/y. One patient of 12 (8%) in the β-blocker group had a rate that exceeded the mean for the overall group compared with eight patients of 15 (53%) in the group with no β-blockade. This difference was statistically significant. Thus, β-blockade may be associated with a decreased AAA growth rate in this small, retrospective study.

(Arch Surg 1988;123:606-609)

Author Affiliations
From the Department of Surgery, Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication Jan 29, 1988.

Read before the Annual Meeting of the New England Surgical Society, Bretton Woods, NH, Sept 19, 1987.

Reprint requests to Department of Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510 (Dr Tilson).

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