This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Robert J. Havlik, MD; C. Elton Cahow, MD; Barbara K. Kinder, MD

Arch Surg. 1988;123(5):626-630.

Abstract
• Diagnosis and management of pheochromocytoma, once dangerous and uncertain, have been dramatically altered in recent years by advances in imaging, assays, and pharmaceuticals. During the past ten years we have treated 18 patients who had pheochromocytoma. Biochemical diagnosis was made In all patients by measurement of 24-hour urinary total catecholamine excretion or by epinephrine-norepinephrine fractionation. Determination of epinephrine-norepinephrine ratios was instrumental in making the diagnosis of pheochromocytoma in two patients in whom total catecholamine levels were normal. Localization of the pheochromocytoma in the most recently treated cases was accomplished by ultrasound, computed tomography, or iodine I 131 iobenguane (iodine I 131 metaiodobenzylguanidine) scanning. Nine patients in the series were prepared for surgery with phenoxybenzamine hydrochloride and six with prazosin hydrochloride. Preoperative total -adrenergic blockade with phenoxybenzamine offered no advantage over selective blockade with prazosin in terms of perioperative fluid requirements or intraoperative hemodynamlc stability.

(Arch Surg 1988;123:626-630)

Author Affiliations
From the Department of Surgery, Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication Jan 29, 1988.

Read before the Annual Meeting of the New England Surgical Society, Bretton Woods, NH, Sept 12, 1987.

Reprint requests to Department of Surgery, Yale University School of Medicine, 333 Cedar St, PO Box 3333, New Haven, CT 06510-8062 (Dr Kinder).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hemorrhagic Pheochromocytoma Associated with Systemic Corticosteroid Therapy and Presenting as Myocardial Infarction with Severe Hypertension
Brown et al.
J. Clin. Endocrinol. Metab. 2005;90:563-569.
ABSTRACT | FULL TEXT  

Sensitivity of Diagnostic and Localization Tests for Pheochromocytoma in Clinical Practice
Witteles et al.
Arch Intern Med 2000;160:2521-2524.
ABSTRACT | FULL TEXT