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Evaluation of Naloxone Therapy for Escherichia coli Sepsis in the Baboon
Lerner B. Hinshaw, PhD;
Linda T. Archer, PhD;
Beverly K. Beller;
Alvin C. K. Chang;
Dayl J. Flournoy, PhD;
Richard B. Passey, PhD;
Joseph B. Long, PhD;
John W. Holaday, PhD
Arch Surg. 1988;123(6):700-704.
Abstract
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• This study evaluated the effects of naloxone hydrochloride in the treatment of Escherichia coli–induced shock in baboons. The baboons were studied for 12 hours and monitored for survival times. All baboons were intravenously infused for two hours with E coli and treated as follows: group 1, E coli (control); group 2, E coli plus naloxone hydrochloride, 0.5 mg/kg bolus plus 0.5 mg/kg/h for 9.5 hours; and group 3, E coli plus naloxone hydrochloride, 2.0 mg/kg bolus plus 2.0 mg/kg/h for 3.8 hours. Naloxone was administered after arterial pressure had reached the nadir (more than two hours following initiation of E coli infusion). Mean arterial pressure was supported by the lower dose of naloxone; however, sustained leukopenia and neutropenia were not reversed by its infusion. Naloxone prevented the increase in plasma β-endorphin level and blunted the increase in plasma cortisol level. Despite these effects, naloxone did not prevent multiple-organ disease and did not decrease mortality.
(Arch Surg 1988;123:700-704)
Author Affiliations
From the Oklahoma Medical Research Foundation (Dr Hinshaw), the Veterans Administration Medical Center (Drs Archer, Flournoy, and Passey and Ms Beller), and the University of Oklahoma Health Sciences Center (Dr Passey and Mr Chang), Oklahoma City; and the Walter Reed Army Institute of Research (Drs Long and Holaday), Washington, DC.
Footnotes
Accepted for publication July 8, 1987.
Read before the Federation of American Societies for Experimental Biology, St Louis, April 17, 1986.
Reprint requests to Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104 (Dr Hinshaw).
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