This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (28)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Effect on Nude Mouse–Supported Human Bladder Cancer Heterografts

Anurag K. Das, MD; Philip J. Walther, MD, PhD; Niall J. Buckley, MD; Susan H. M. Poulton

Arch Surg. 1989;124(1):107-110.

Abstract
• Although studies done in tissue culture (in vitro) have shown synergism between recombinant human tumor necrosis factor (rhTNF) and chemotherapeutic agents, whether such synergism exists in a complex in vivo environment with acceptable toxic side effects has not been determined, to our knowledge. The effect of rhTNF alone and in combination with cisplatin, etoposide, doxorubicin, or dactinomycin on the growth of heterotransplants of human bladder transitional cell carcinoma was studied using a modified subrenal capsule assay in athymic nude mice. Only etoposide potentiated rhTNF cytotoxicity; no increase in host toxicity was noted. Variably enhanced toxic side effects were seen with other combinations. It is concluded that rhTNF combined with etoposide may have potential clinically exploitable therapeutic "synergism" in the treatment of advanced bladder cancer.

(Arch Surg 1989;124:107-110)

Author Affiliations
From the Departments of Surgery (Urology) (Drs Das, Walther, and Buckley and Ms Poulton) and Pathology (Dr Walther), Medical Research Service, Durham Veterans Administration Medical Center and Duke University School of Medicine (Dr Walther), Durham, NC.

Footnotes
Accepted for publication July 8, 1988.

Read before the Annual Meeting of the Society of Surgical Oncology, New Orleans, May 23, 1988.

Reprint requests to Box 3314, Duke University Medical Center, Durham, NC 27710 (Dr Walther).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?