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Armando Sardi, MD; Mark Workman; Cathy Mojzisik, RN, MS; George Hinkle, RPh; Carol Nieroda, MD; Edward W. Martin, Jr, MD

Arch Surg. 1989;124(1):55-59.

Abstract
• Since 1986, 32 patients with metastatic colorectal cancer have undergone second-look radioimmunoguided surgery (RIGS system). The primary tumor was located in the right and transverse colon in 11 patients, left and sigmoid colon in 16, and rectum in five. The carcinoembryonic antigen level was elevated in 30 patients (94%); all patients underwent a computed tomographic scan of the abdomen and pelvis. The overall sensitivity of the computed tomographic scan was 41% (abdomen other than liver, 27%; liver, 58%; and pelvis, 22%). The RIGS system identified recurrent tumor in 81% of the patients. The most common site of metastasis was the liver (41%), independent of the primary location. Local/regional recurrences alone accounted for 40% of all recurrences. In six patients (18%), recurrent tumor was found only with the RIGS system. The RIGS system is more dependable in localizing clinically obscure metastases than other methods, and carcinoembryonic antigen testing remains the most accurate preoperative method to indicate suspected recurrences.

(Arch Surg 1989;124:55-59)

Author Affiliations
From the Department of Surgery, Division of Surgical Oncology, The Ohio State University College of Medicine, Columbus. Drs Sardi and Nieroda are fellows of the American Cancer Society. Dr Sardi is now with the Ochsner Clinic, New Orleans.

Footnotes
Accepted for publication July 8, 1988.

Read before the Annual Meeting of the Society of Surgical Oncology, New Orleans, May 24, 1988.

Reprint requests to Department of Surgery, Division of Surgical Oncology, The Ohio State University College of Medicine, N-924 Doan Hall, 410 W Tenth Ave, Columbus, OH 43210 (Dr Martin).

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