 |
|
Natural Killer Sensitivity of Colorectal Carcinoma TargetsCorrelation With Degree of Differentiation
Darius J. Bägli, MD, CM;
Glenn D. Steele, Jr, MD, PhD;
Teresa Barlozzari, PhD
Arch Surg. 1989;124(1):89-93.
Abstract
• Lymphocytes with natural killer (NK) ability recognize a wide range of target cells; however, the mediators of specific target recognition are still largely unknown. Despite the diversity of the NK target repertoire, it is typified by cells of relatively immature phenotype. The purpose of this study was to determine if colorectal carcinoma (CRC) targets were sensitive to spontaneous lysis by fresh human NK effector cells and to observe the role of CRC differentiation in this process. Results demonstrated that poorly differentiated CRC targets were susceptible to NK-mediated lysis whereas CRC targets with more differentiated structure were NK resistant. In addition, chemical induction of a more mature CRC phenotype confers NK resistance on a previously NK-susceptible target. This maturation-related modulation of NK sensitivity can provide a model with which to further study interaction between NK cells and CRC targets.
(Arch Surg 1989;124:89-93)
Author Affiliations
From the Laboratory of Cancer Biology, Department of Surgery, New England Deaconess Hospital and Harvard Medical School, Boston.
Footnotes
Accepted for publication Sept 15, 1988.
Read before the Annual Meeting of the Society of Surgical Oncology, New Orleans, May 23, 1988.
Reprint requests to Department of Surgery, Harvard Medical School, New England Deaconess Hospital, 50 Binney St, Boston, MA 02115 (Dr Bägli).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Inhibition of Sialic Acid Incorporation Prevents Hepatic Metastases
Wagner et al.
Arch Surg 1990;125:351-354.
ABSTRACT
|
