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A Clinical Review and Meta-Analysis

Patrick Twomey, MD; Mary Burchell, MD; Dale Strawn, MD; James Guernsey, MD

Arch Surg. 1989;124(10):1174-1179.

Abstract
• We reviewed the factors influencing local control of potentially curable rectal cancer in 106 patients. There was improvement in stage-adjusted local control associated with increasing use of adjuvant radiation therapy. A meta-analysis of the English-language literature through 1988 also supported the effectiveness of adjuvant radiation therapy in all but the lowest-risk patients. No effect on survival was identified in either analysis, but a reduction of up to 40% in local recurrence rates may be achieved with doses of 3000 cGy or more.

(Arch Surg. 1989;124:1174-1179)

Author Affiliations
From the Department of Surgery, University of California-Davis, East Bay, and Martinez (Calif) Veterans Administration Hospital.

Footnotes
Accepted for publication July 6, 1989.

Read before the 60th Annual Meeting of the Pacific Coast Surgical Association, Vancouver, Canada, February 22, 1989.

Reprint requests to Department of Surgery, University of California-Davis, East Bay, Martinez Veterans Administration Hospital, Martinez, CA 94553 (Dr Twomey).