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Kelly H. Kopald, MD; Lester J. Layfield, MD; Renee Mohrmann, MD; Leland J. Foshag, MD; Armando E. Giuliano, MD

Arch Surg. 1989;124(10):1201-1205.

Abstract
• The final histologic diagnoses of 486 patients who underwent thyroidectomy at UCLA Medical Center from March 1975 to August 1988 were reviewed. There were 146 patients with a diagnosis of thyroid malignant neoplasm. All patients who had preoperative fine-needle aspiration cytologic evaluation, intraoperative frozen section analysis, or both were included in the present study. Carcinoma was diagnosed by frozen section in 87 (69%) of 126 cases. Frozen section analysis was incorrect in 39 (31%) of 126 cases. Fine-needle aspiration was performed in 62 patients. A malignant neoplasm was identified by fine-needle aspiration in 44 (71%) of 62 cases. Fifty-six patients had both preoperative fine-needle aspiration and intraoperative frozen section analysis, and carcinoma was detected by both methods in 32 (57%) of 56 cases. Fine-needle aspiration cytologic evaluation is extremely valuable in the diagnosis of thyroid cancer and is at least as accurate as frozen section analysis with less morbidity and expense. When fine-needle aspiration demonstrates malignant neoplasm, thyroid resection may be planned with confidence.

(Arch Surg. 1989;124:1201-1205)

Author Affiliations
From the Department of Surgery, Division of General Surgery (Drs Kopald, Foshag, and Giuliano), and the Department of Pathology (Drs Layfield and Mohrmann), UCLA School of Medicine.

Footnotes
Accepted for publication July 6, 1989.

Read before the 60th Annual Meeting of the Pacific Coast Surgical Association, Vancouver, Canada, February 22, 1989.

Reprint requests to UCLA Medical Center, Division of General Surgery, Room 72-172 CHS, Los Angeles, CA 90024 (Dr Giuliano).

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