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Treatment With Yttrium 90—Labeled Anti—Carcinoembryonic Antigen Antibody

David M. Hyams, MD; Jose M. Esteban, MD; Barbara G. Beatty, PhD; Philip M. Wanek, RPh; J. David Beatty, MD

Arch Surg. 1989;124(2):175-179.

Abstract
• Nude mice bearing diffuse intraperitoneal carcinomatosis of the human colon cancer cell line LS174T were treated with an anti–carcinoembryonic antigen monoclonal antibody (MAB) that was labeled with yttrium 90 (⁹⁰Y-ZCE025). Control animals were either untreated or treated with nonspecific⁹⁹Y-MAB (⁹⁰Y-96.5c). The median survival (MS) for untreated animals was 26 days. The MS for specific and nonspecific therapy that consisted of 120 µCi of⁹⁰Y-MAB was 69 and 34 days, respectively. No significant improvement in the MS was observed with a second 120-µCi administration of⁹⁰Y-MAB given two weeks later. A decreased MS was observed with 80 µCi of⁹⁰Y-MAB given every four days for three cycles. In each category, specific therapy had a significant advantage over nonspecific therapy in increased effectiveness and decreased toxicity. The⁹⁰Y-ZCE025 therapy gave an increased life span of almost 200%. The therapeutic effects with different dosing regimens have important implications for treatment planning.

(Arch Surg 1989;124:175-179)

Author Affiliations
From the Departments of General Oncologic Surgery (Drs Hyams, B. G. Beatty, and J. D. Beatty) and Anatomic Pathology (Dr Esteban), City of Hope National Medical Center, Duarte, Calif, and Hybritech Inc, San Diego (Mr Wanek).

Footnotes
Accepted for publication Nov 29, 1988.

Read before the Annual Meeting of the Society of Surgical Oncology, New Orleans, May 23, 1988.

Reprint requests to Department of General Oncologic Surgery, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010 (Dr J. D. Beatty).

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ABSTRACT