This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (61)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

James S. McCaughan, Jr, MD; Jerry T. Guy, MD; William Hicks, MD; Leslie Laufman, MD; Thomas A. Nims, MD; John Walker

Arch Surg. 1989;124(2):211-216.

Abstract
• Twenty-seven patients with cutaneous and subcutaneous malignant neoplasms were treated with photodynamic therapy. Therapy was administered to 248 areas during a total of 72 separate treatment sessions after patients received a total of 45 injections of sensitizer. Seven patients had basal cell carcinoma, three had squamous cell carcinoma, three had malignant melanoma, one had liposarcoma, and 12 had breast cancers. One patient had Bowen's disease. Treatment was given either by surface radiation or interstitially. One month after treatment, 48 (67%) of the treatment sessions resulted in a complete response (no clinical evidence of tumor), and 19 (26%) resulted in a partial response (>50% reduction in the number or size of tumors). Fifteen patients were examinable 12 months after treatment, and in this group, 31 treatment sessions were evaluated as a complete response one month after therapy, 15 (48%) of which retained this status at one year after treatment. By comparing the ability of different light-delivery instrumentation, it was concluded that the Yellow Springs radiometer (Yellow Springs Instruments, model 65A Yellow Springs, Ohio) provided the most reliable spot power density readings. Straight-tipped fibers are nonhomogeneous and can result in overtreatment of the central area with necrosis and pain and in undertreatment of the periphery.

(Arch Surg 1989;124:211-216)

Author Affiliations
From the Laser Medical Research Foundation, Columbus, Ohio.

Footnotes
Accepted for publication Sept 2, 1988.

Read before the Annual Meeting of the Society of Surgical Oncology, New Orleans, May 23, 1988.

Reprint requests to 323 E Town St, Columbus, OH 43215 (Dr McCaughan).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Lasers in Dermatology--1993
Hruza et al.
Arch Dermatol 1993;129:1026-1035.
ABSTRACT  

Photodynamic Therapy for the Treatment of Basal Cell Carcinoma
Wilson et al.
Arch Dermatol 1992;128:1597-1601.
ABSTRACT  

Photodynamic Therapy in Dermatology: Shedding a Different Light on Skin Disease
Lui and Anderson
Arch Dermatol 1992;128:1631-1636.
ABSTRACT  

Photodynamic Therapy to Treat Tumors of the Extrahepatic Biliary Ducts: A Case Report
McCaughan et al.
Arch Surg 1991;126:111-113.
ABSTRACT  

Squamous Cell Carcinoma of the Lower Lip Involving a Large Cutaneous Surface: Photodynamic Therapy as an Alternative Therapy
Gross et al.
Arch Dermatol 1990;126:1148-1150.
ABSTRACT