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Richard W. Schwartz, MD; Nancy M. Logan; Paul J. Johnson, MD; William E. Strodel, MD; Joseph G. Fine, MD; Andris Kazmers, MD; Gordon L. Hyde, MD

Arch Surg. 1989;124(4):434-437.

Abstract
• Pentoxifylline, a new trisubstituted methylxanthine derivative known for its hemorrheologic action, has been shown to improve exercise tolerance in atherosclerotic patients. We examined the response of diabetic atherosclerotic patients to pentoxifylline administration, measured by Doppler waveform analysis and exercise tolerance. Standard exercise tolerance and Doppler waveform analytic studies of the lower extremity, specifically the right dorsalis pedis artery, were performed before and after three months of pentoxifylline administration (400 mg three times a day). The study group comprised ten subjects (six men and four women) with a mean (±SD) age of 60±3.3 years. Data were analyzed using a paired Student t test. All ten subjects showed a significant increase in exercise tolerance after pentoxifylline treatment. Eight of ten subjects demonstrated a significant increase in right dorsalis pedis arterial flow.

(Arch Surg 1989;124:434-437)

Author Affiliations
From the Department of Surgery, University of Kentucky Chandler Medical Center, Lexington, Ky.

Footnotes
Accepted for publication Dec 12, 1988.

Read before the 12th Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Minneapolis, May 16, 1988.

Reprint requests to Department of Surgery, University of Kentucky, 800 Rose St, Lexington, KY 40536-0084 (Dr Schwartz).

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