You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 124 No. 4, April 1989 TABLE OF CONTENTS
  Archives
  •  Online Features
  PAPERS READ BEFORE THE 12TH ANNUAL SURGICAL SYMPOSIUM OF THE ASSOCIATION OF VETERANS ADMINISTRATION SURGEONS, MINNEAPOLIS, MINN, MAY 12 TO MAY 16, 1988
 This Article
 •References
 •Full text PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Pentoxifylline Increases Extremity Blood Flow in Diabetic Atherosclerotic Patients

Richard W. Schwartz, MD; Nancy M. Logan; Paul J. Johnson, MD; William E. Strodel, MD; Joseph G. Fine, MD; Andris Kazmers, MD; Gordon L. Hyde, MD

Arch Surg. 1989;124(4):434-437.


Abstract

• Pentoxifylline, a new trisubstituted methylxanthine derivative known for its hemorrheologic action, has been shown to improve exercise tolerance in atherosclerotic patients. We examined the response of diabetic atherosclerotic patients to pentoxifylline administration, measured by Doppler waveform analysis and exercise tolerance. Standard exercise tolerance and Doppler waveform analytic studies of the lower extremity, specifically the right dorsalis pedis artery, were performed before and after three months of pentoxifylline administration (400 mg three times a day). The study group comprised ten subjects (six men and four women) with a mean (±SD) age of 60±3.3 years. Data were analyzed using a paired Student t test. All ten subjects showed a significant increase in exercise tolerance after pentoxifylline treatment. Eight of ten subjects demonstrated a significant increase in right dorsalis pedis arterial flow.

(Arch Surg 1989;124:434-437)



Author Affiliations

From the Department of Surgery, University of Kentucky Chandler Medical Center, Lexington, Ky.


Footnotes

Accepted for publication Dec 12, 1988.

Read before the 12th Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Minneapolis, May 16, 1988.

Reprint requests to Department of Surgery, University of Kentucky, 800 Rose St, Lexington, KY 40536-0084 (Dr Schwartz).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia
Steffen et al.
J. Appl. Physiol. 2008;105:1950-1958.
ABSTRACT | FULL TEXT  

Ability of Ankle-Brachial Index to Detect Lower-Extremity Atherosclerotic Disease Progression
McLafferty et al.
Arch Surg 1997;132:836-841.
ABSTRACT  

Hemorheologic Approach in the Treatment of Diabetic Foot Ulcers
Ramani et al.
ANGIOLOGY 1993;44:623-626.
ABSTRACT  

Vasodilator Action of Pentoxifylline on Microcirculation of Rat Cremaster Muscle
Sonkin et al.
ANGIOLOGY 1992;43:462-469.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1989 American Medical Association. All Rights Reserved.