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William W. Hampton, MD; Michael C. Townsend, MD; William J. Schirmer, MD; David M. Haybron, MD; Donald E. Fry, MD

Arch Surg. 1989;124(4):458-459.

Abstract
• Hepatic dysfunction following cardiopulmonary bypass (CPB) is a relatively frequent finding, and jaundice occurring after CPB is associated with an increased mortality rate. PostCPB jaundice may be a consequence of inadequate liver perfusion during CPB. To evaluate the potential impact of CPB on effective hepatic blood flow, 10 patients undergoing CPB for cardiac procedures were studied. Effective hepatic blood flow was measured in each patient during the operative procedure but before institution of CPB and during CPB as well. Effective hepatic blood flow was measured by the galactose clearance technique. Blood lactate and pyruvate levels were also measured before and during CPB. During CPB, effective hepatic blood flow was consistently reduced by an average of 19%. Although for most patients this reduction seems well tolerated, in a minority of patients it may contribute to postoperative hepatic dysfunction.

(Arch Surg. 1989;124:458-459)

Author Affiliations
From the Department of Surgery, Case Western Reserve University and the Cleveland (Ohio) Veterans Administration Medical Center. Dr Fry is now with the University of New Mexico School of Medicine, Albuquerque.

Footnotes
Accepted for publication November 14, 1988.

Read before the 12th Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Minneapolis, Minn, May 13, 1988.

Reprint requests to Department of Surgery, University of New Mexico School of Medicine, 2211 Lomas Blvd NE, Albuquerque, NM 87131 (Dr Fry).

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