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Richard J. Davies, MD; Renah Joseph; Horacio Asbun, MD; Marc Sedwitz, MD

Arch Surg. 1989;124(4):480-484.

Abstract
• Alterations in ionic conductance may represent an early mitogenic signal; therefore, impedance analysis was used to examine differences in the electrical properties of the distal colon in a cancer-susceptible (CF₁) and a cancer-resistant (DBA) strain of mouse following administration of the carcinogen dimethylhydrazine. The electrical conductance of the surface colonic epithelium increased in CF₁ mice from a mean (±SEM) of 41.1 ±3.0 milliSiemens.cm^–2 (mS.cm^–2) in controls to 52.6 ±3.1 mS.cm^–2 following dimethylhydrazine treatment. The conductance decreased in the cancer-resistant DBA group from 154.6±44.1 mS.cm^–2 in controls to 35.1 ±17.2 mS.cm^–2 following dimethylhydrazine treatment. This difference in response to the carcinogen may partly explain differences in susceptibility noted between these two species. Epithelial impedance analysis may be of use in the early detection of the colon at risk for subsequent cancer development.

(Arch Surg 1989;124:480-484)

Author Affiliations
From the University of California Medical Center and the Veterans Administration Medical Center, San Diego.

Footnotes
Accepted for publication Dec 12, 1988.

Read before the 12th Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Minneapolis, May 13, 1988.

Reprint requests to Division of Surgical Oncology, Department of Surgery, H891B, University of California Medical Center, 225 Dickinson St, San Diego, CA 92103 (Dr Davies).

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