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Dean M. Govostis, MD; Dennis F. Bandyk, MD; Thomas M. Bergamini, MD; Jonathan B. Towne, MD

Arch Surg. 1989;124(4):490-493.

Abstract
• The influence of venous patching on luminal prostacyclin (PGI₂) and thromboxane A₂ (TBX) production of endarterectomized arteries was studied in a canine model. Fifteen dogs underwent bilateral common carotid endarterectomies. In each dog, one artery was closed primarily and the contralateral artery was closed by vein-patch angioplasty. At six and 12 weeks after operation, luminal prostanoid production from the venous patch, adjacent endarterectomized artery, and control artery and vein was measured by radioimmunoassay for 6-keto-prostaglandin F₁ and thromboxane B₂. Venous patches underwent "incomplete" biochemical adaptation with decreased luminal production of PGI₂ compared with control and endarterectomized arteries. Thromboxane production from venous patches was increased compared with normal vein but similar to control and endarterectomized arteries. At six weeks, PGI₂ production of vein-patched arterial segments was increased compared with arteries closed primarily. These data indicate that vein-patch angioplasty favorably influences surface thrombogenicity of healing, endarterectomized arteries and support its use in reparative carotid surgery.

(Arch Surg 1989;124:490-493)

Author Affiliations
From the Surgical Service, Veterans Administration Medical Center (Drs Bandyk, Bergamini, and Towne), and the Department of Surgery, Medical College of Wisconsin (Drs Govostis, Bandyk, and Towne), Milwaukee.

Footnotes
Accepted for publication Nov 7, 1988.

Read before the 12th Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Minneapolis, May 13, 1988.

Reprint requests to Department of Surgery, MCMC, 8700 W Wisconsin Ave, Milwaukee, WI 53226 (Dr Bandyk).

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