Immunocytochemical analysis of estrogen receptors in human breast carcinomas. Evaluation of 130 cases and review of the literature regarding concordance with biochemical assay and clinical relevance
D. C. Allred, M. A. Bustamante, C. O. Daniel, H. V. Gaskill and A. B. Cruz Jr
Department of Pathology, University of Texas Health Science Center, San Antonio 78284.
An estrogen receptor-immunocytochemical assay (ER-ICA) was performed on
frozen sections of 130 samples of human breast carcinoma. A standard
dextran-coated charcoal assay (DCCA) was performed on the same samples.
Concordance of results between the tests was 91%. The sensitivity and
specificity of the ER-ICA, compared with the DCCA, were 92% and 89%,
respectively. We describe the ER-ICA technique and review the literature
regarding the use of the ER-ICA in evaluating breast cancer with respect to
the agreement of results with the DCCA, the nature of discordant results,
the ability to predict the clinical response to hormone therapy, and the
ability to predict disease-free survival. The combined experience of many
studies has shown that the ER-ICA is a highly specific and sensitive method
for measuring the level of ERs in breast tumors with a high level of
agreement with the DCCA. Early experience has suggested that the ER-ICA can
predict the response to hormone therapy and disease-free survival, as well
as or better than the DCCA. The evaluation of receptor heterogeneity, made
possible by the ER-ICA, may enhance our ability to discriminate ER-positive
tumors with a relatively high risk of recurrence.
Quantitative Imaging of Estrogen Receptor Expression in Breast Cancer with PET and 18F-Fluoroestradiol
Peterson et al.
JNM 2008;49:367-374.
ABSTRACT
| FULL TEXT
The breast cancer continuum in hormone-receptor positive breast cancer in postmenopausal women: evolving management options focusing on aromatase inhibitors
Rugo
Ann Oncol 2008;19:16-27.
ABSTRACT
| FULL TEXT
High Progesterone Receptor Expression Correlates to the Effect of Adjuvant Tamoxifen in Premenopausal Breast Cancer Patients
Stendahl et al.
Clin. Cancer Res. 2006;12:4614-4618.
ABSTRACT
| FULL TEXT
Reliance on Hormone Receptor Assays of Surgical Specimens May Compromise Outcome in Patients With Breast Cancer
Mann et al.
JCO 2005;23:5148-5154.
ABSTRACT
| FULL TEXT
A Predictive Model for the Development of Hormone-Responsive Breast Cancer
Gorla et al.
Ann. Surg. Oncol. 2005;12:48-56.
ABSTRACT
| FULL TEXT
Use of Electric Bedding Devices and Risk of Breast Cancer in African-American Women
Zhu et al.
Am J Epidemiol 2003;158:798-806.
ABSTRACT
| FULL TEXT
Frequency of oestrogen and progesterone receptor positivity by immunohistochemical analysis in 7016 breast carcinomas: correlation with patient age, assay sensitivity, threshold value, and mammographic screening
Rhodes et al.
J. Clin. Pathol. 2000;53:688-696.
ABSTRACT
| FULL TEXT
Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer
Harvey et al.
JCO 1999;17:1474-1474.
ABSTRACT
| FULL TEXT
