 |
|
Analysis of Potential Risks Associated With 7.5% Sodium Chloride Resuscitation of Traumatic Shock
Mary J. Vassar, RN, MS;
Colleen A. Perry, RN;
James W. Holcroft, MD
Arch Surg. 1990;125(10):1309-1315.
Abstract
| |
• We evaluated the potential side effects of rapidly infusing 250 mL of either 7.5% sodium chloride or 7.5% sodium chloride per 6% dextran 70, using lactated Ringer's as the control, to 106 critically injured patients in two prospective double-blinded emergency department trials. Eight patients had a significant hyperchloremic acidemia in association with infusion of the hypertonic solutions, but all eight were moribund before infusion and many factors other than hyperchloremia could have contributed to their acidemia. Other blood chemistry changes that might have been associated with the hypertonic solutions, such as hyperosmolality or hypernatremia, were made insignificant by other factors, such as high blood alcohol levels or concomitant administration of sodium bicarbonate. There were no cases of central pontine myelinolysis; bleeding was not potentiated. There was no difficulty with crossmatching of blood. No anaphylactoid reactions occurred. In a setting of limited volume resuscitation, the solutions are likely to have a favorable risk-to-benefit ratio.
(Arch Surg. 1990;125:1309-1315)
Author Affiliations
From the Department of Surgery, University of California, Davis, Medical Center, Sacramento, Calif.
Footnotes
Accepted for publication May 23, 1990.
Presented at the 61st meeting of the Pacific Coast Surgical Association, Laguna Niguel, Calif, February 19, 1990.
Address correspondence to Department of Surgery, University of California Davis Medical Center, 4301 X St, Rm 2310, Sacramento, CA 95817.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Traumatic brain injury: assessment, resuscitation and early management
Moppett
Br J Anaesth 2007;99:18-31.
ABSTRACT
| FULL TEXT
Hypertonic-Hyperoncotic Solutions Improve Cardiac Function in Children After Open-Heart Surgery
Schroth et al.
Pediatrics 2006;118:e76-e84.
ABSTRACT
| FULL TEXT
The use of hypertonic saline for treating intracranial hypertension after traumatic brain injury.
White et al.
Anesth. Analg. 2006;102:1836-1846.
ABSTRACT
| FULL TEXT
Fluid choice for resuscitation of the trauma patient: a review of the physiological, pharmacological, and clinical evidence: [Le choix du liquide pour la reanimation du patient polytraumatise : une revue des donnees physiologiques, pharmacologiques et cliniques]
Boldt
Canadian J. Anesthesia 2004;51:500-513.
ABSTRACT
| FULL TEXT
The Effect of Hypernatremia on Liver Allografts in Rats
Jawan et al.
Anesth. Analg. 2002;95:1169-1172.
ABSTRACT
| FULL TEXT
The role of hypertonic saline dextran in trauma resuscitation
Perera and Porter
Trauma 2002;4:189-201.
ABSTRACT
The Comparison of Hypertonic Saline (7.5%) and Normal Saline (0.9%) for Initial Fluid Administration Before Spinal Anesthesia
Jarvela et al.
Anesth. Analg. 2000;91:1461-1465.
ABSTRACT
| FULL TEXT
Effects of Hypertonic Saline Hydroxyethyl Starch Solution and Mannitol in Patients With Increased Intracranial Pressure After Stroke
Schwarz et al.
Stroke 1998;29:1550-1555.
ABSTRACT
| FULL TEXT
A Medical Disaster Response to Reduce Immediate Mortality after an Earthquake
Schultz et al.
NEJM 1996;334:438-444.
FULL TEXT
7.5% Sodium Chloride/Dextran for Resuscitation of Trauma Patients Undergoing Helicopter Transport
Vassar et al.
Arch Surg 1991;126:1065-1072.
ABSTRACT
|
