This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (6)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

M. H. Shokouh-Amiri, MD; S. Rahimi-Saber, MD; C. Palnaes Hansen, MD; P. Skov Olsen, MD, PhD; S. Lindkaedr Jensen, MD, PhD

Arch Surg. 1990;125(11):1472-1474.

Abstract
• Susceptibility to Streptococcus pneumoniae infection was studied in 11 groups of rats allocated to sham operation, splenectomy, or splenic autotransplantation of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% of the removed spleen. Three months later, all rats were exposed intravenously to type 1 Streptococcus pneumoniae (median lethal dose, LD50, for control group). Survivors were killed 13 days after the bacterial challenge. Autopsy showed that more splenic tissue was recovered in rats that received less than 50% splenic tissue compared with those that received 50% or more. More survivors were found among sham-operated rats (47.5%; 95% confidence intervals, 32 to 68) and rats that had 40% splenic tissue implanted (35%; confidence interval, 20 to 54) or those that were found to have regenerated 40% splenic tissue. We conclude that 40% of the spleen should be autotransplanted to protect the rat optimally against infection after splenectomy.

(Arch Surg. 1990;125:1472-1474)

Author Affiliations
From the Department of Surgical Gastroenterology, Rigshospitalet, University of Copenhagen (Drs Shokouh-Amiri, Rahimi-Saber, Hansen, and Olsen); and the Department of Surgical Gastroenterology, Aarhus Kommunehospital, University of Aarhus (Dr Jensen), Denmark.

Footnotes
Accepted for publication May 13, 1990.

Reprint requests to Department of Surgery, Aarhus Kommunehospital, DK-8000 Aarhus C, Denmark (Dr Shokouh-Amiri).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?