This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (12)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

J. Scott Flint, MD; Garth H. Ballantyne, MD; James R. Goldenring, MD, PhD; L. Peter Fielding, MD; Irvin M. Modlin, MD, PhD

Arch Surg. 1990;125(12):1561-1563.

Abstract
• We have studied the effect of neuropeptide Y on basal and vasoactive intestinal polypeptide–stimulated changes in the short-circuit current of strips of colonic mucosa from New Zealand white rabbits mounted in Ussing chambers. When administered to the basolateral surface, neuropeptide Y is found to decrease basal short-circuit current. Neuropeptide Y inhibits vasoactive intestinal peptide–stimulated increases in short-circuit current in a concentration-dependent fashion by a tetrodotoxin-insensitive mechanism. Also, neuropeptide Y inhibited increases in short-circuit current produced by direct stimulation of adenylate cyclase with forskolin. Furthermore, neuropeptide Y prevents vasoactive intestinal peptide–stimulated increases in tissue cyclic adenosine monophosphate levels. These results indicate that neuropeptide Y administered to the basolateral membrane inhibits vasoactive intestinal peptide–stimulated short-circuit current changes by a tetrodotoxin-insensitive mechanism that decreases tissue levels of cyclic adenosine 3',5'-monophosphate.

(Arch Surg. 1990;125:1561 -1563)

Author Affiliations
From St Mary's Hospital, Waterbury, Conn (Drs Flint and Fielding), the Gastrointestinal Surgery Research Unit, Department of Surgery, Yale University School of Medicine, New Haven, Conn (Drs Ballantyne, Goldenring, and Modlin); and West Haven (Conn) Veterans Affairs Medical Center (Drs Ballantyne, Goldenring, and Modlin).

Footnotes
Accepted for publication July 21, 1990.

Read before the 14th Annual Surgical Symposium of the Association of Veterans Affairs Surgeons, Charleston, SC, May 7, 1990.

Reprint requests to Department of Surgery (112), West Haven Veterans Affairs Medical Center, West Haven, CT 06510 (Dr Ballantyne).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?