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Lucy Wortham James Clinical Research Award Lecture

Ernst L. Wynder, MD

Arch Surg. 1990;125(2):163-169.

Abstract
• This presentation reflects four decades of research on the origins and prevention of major human cancers linked to tobacco use and nutritional factors. Observations in the 1950s went on to prove the causal relationship between cigarette smoking and lung cancer. Attempts to lower the cancer risk by product modification have shown some promise, but an absolute risk reduction can be attained only by abstinence from tobacco use. The role of dietary fat as a risk factor for breast cancer is highlighted as an example of the link between nutrition and cancer. Preventive strategies of dietary modification need to delineate the roles of specific types of dietary fats in mammary carcinogenesis. Low-fat diets in conjunction with chemotherapy and ovarian ablation may even be effective in preventing metastasis or recurrence of breast cancer after surgery in premenopausal patients. Health education in schools and health promotion efforts involving all segments of the community need to be pursued as primary preventive strategies for cancer control, along with efforts toward product modification and research on chemoprevention of cancer.

(Arch Surg. 1990;125:163-169)

Author Affiliations
From the American Health Foundation, New York, NY.

Footnotes
Accepted for publication September 23, 1989.

Read before the annual meeting of the Society of Surgical Oncology, San Francisco, Calif, May 23, 1989.

Reprint requests to the American Health Foundation, 320 E 43rd St, New York, NY 10017 (Dr Wynder).

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