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A Prospective Study

Dido Franceschi, MD; Joseph Crowe, MD; Robert Zollinger, MD; Renate Duchesneau, MD; Robert Shenk, MD; Gladys Stefanek, RN; Jerry M. Shuck, MD, DSc

Arch Surg. 1990;125(2):170-173.

Abstract
• We prospectively studied 239 consecutive patients who underwent breast biopsy for 277 nonpalpable lesions characterized by mammographic microcalcifications. Clinical and mammographic characteristics were correlated with histologic findings in an attempt to identify patients more likely to have early breast cancer. The distribution of clinical risk factors was equal between patients with benign or malignant outcomes. The predominant Wolfe pattern on mammography was P2 (38%); however, no relationship was observed between the Wolfe pattern and malignancy. A marked correlation was observed between malignancy and small lesions, more than 15 calcifications, and calcifications in a linear or branching pattern. Twenty-four percent (n = 67) of the biopsy specimens contained either ductal or lobular breast cancer. This study highlights the necessity of an aggressive approach toward suspicious calcifications found by mammography.

(Arch Surg. 1990;125:170-173)

Author Affiliations
From the University Hospitals of Cleveland (Ohio), Case Western Reserve University.

Footnotes
Accepted for publication November 15, 1989.

Read before the annual meeting of the Society of Surgical Oncology, San Francisco, Calif, May 15, 1989.

Reprint requests to Department of Surgery, University Hospitals of Cleveland, 2074 Abington Rd, Cleveland, OH 44106 (Dr Crowe).

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