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Joel Lundy, MD; Mary Lozowski, MS; Darya Sadri, MS; Yousri Mishriki, MD

Arch Surg. 1990;125(2):174-176.

Abstract
• The objective of this study was to determine the reliability of immunocytochemical assays of hormone receptors using specimens obtained by fine-needle aspiration of breast cancers. A peroxidase-antiperoxidase immunocytochemical assay was used on 96 aspirates from 47 patients to determine estrogen and progesterone receptor status. Of 27 estrogen receptor–positive cases by steroid-binding analysis, 25 were positive by immunocytochemical assay. Of 21 estrogen receptor–negative cases, 17 were negative by immunocytochemical assay. Of 21 progesterone receptor–positive cases 19 were positive by immunocytochemical assay. Of 27 progesterone receptor–negative cases 25 were negative by immunocytochemical assay. An additional 11 small tumors were evaluated by immunocytochemical assay alone and results were interpretable based on our prior data. With the caveat that a cellular aspirate is obtained, immunocytochemical assay can distinguish hormone receptor–negative and hormone receptor–positive tumors and can be used to assay tumors too small for standard steroid-binding analysis.

(Arch Surg. 1990;125:174-176)

Author Affiliations
From the Department of Surgery, State University of New York–Health Science Center, Stony Brook (Dr Lundy); the Surgical Oncology Laboratory (Dr Lundy and Ms Sadri) and the Department of Pathology (Ms Lozowski and Dr Mishriki), Winthrop-University Hospital, Mineola, NY.

Footnotes
Accepted for publication November 9, 1989.

Read before the annual meeting of the Society of Surgical Oncology, San Francisco, Calif, May 21, 1989.

Reprint requests to 222 Station Plaza N, Suite 603, Mineola, NY 11501 (Dr Lundy).

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