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Changes Associated With Metastasis in B16-F1 Melanoma Cells Surviving Heat
S. David Nathanson, MD;
Robert F. Cerra, PhD;
Fred W. Hetzel, PhD;
Richard J. Zarbo, MD;
John D. Crissman, MD;
Robert Page, MS;
Patricia Anaya, MS;
Patricia Westrick
Arch Surg. 1990;125(2):216-219.
Abstract
• Metastasis to distant sites is mediated by various receptors on the surface of tumor cells. B16-F1 melanomas surviving 43.5°C heat in vitro for 15 minutes and cultured for 10 days bind significantly increased amounts of the basement membrane protein laminin. Motility of heat-resistant B16-F1 cells in vitro toward the chemoattractant laminin is significantly increased. The increased expression of putative laminin receptors may be associated with increased metastasis of melanomas after subcurative hyperthermia.
(Arch Surg. 1990;125:216-219)
Author Affiliations
From the Departments of Surgery (Drs Nathanson and Cerra, and Mss Anaya and Westrick), Neurology (Dr Hetzel and Mr Page), and Pathology (Drs Zarbo and Crissman), Henry Ford Hospital, Detroit, Mich.
Footnotes
Accepted for publication November 4, 1989.
Read before the annual meeting of the Society of Surgical Oncology, San Francisco, Calif, May 22, 1989.
Reprint requests to Henry Ford Hospital, E & R 4, 2799 W Grand Blvd, Detroit, MI 48202 (Dr Nathanson).
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