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Ralph J. Doerr, MD; Hani Abdel-Nabi, MD, PhD; Bruce Merchant, MD, PhD

Arch Surg. 1990;125(2):226-229.

Abstract
• We investigated the utility of scanning with indium 111 labeled to monoclonal antibody in 13 patients after curative resection of colorectal cancer who had elevated carcinoembryonic antigen levels and negative results of clinical workup. Each patient received 1 mg of anti–carcinoembryonic antigen monoclonal antibody type ZCE 025 labeled with 5.5 mCi of¹¹¹In, plus 9 to 39 mg of the same antibody unlabeled. Patients underwent scanning 3 to 7 days after infusion by planar and emission computed tomography. ZCE-025 monoclonal antibody imaging detected tumor recurrence or metastasis in 11 of 13 patients. In one patient the monoclonal antibody scan gave a true-negative result, and in one patient the monoclonal antibody scan failed to disclose a metachronous cecal primary. Tumor sites identified were the pelvis (2 patients), abdominal wall (2), retroperitoneum (1), lymph nodes (3), liver (2), bone (2), and lung (1). The accurate localization of colorectal carcinoma recurrences by means of¹¹¹In ZCE-025 monoclonal antibody demonstrates the usefulness of this diagnostic agent in the setting of elevated carcinoembryonic antigen level and negative results of clinical and radiologic workup.

(Arch Surg. 1990;125:226-229)

Author Affiliations
From the Departments of Surgery (Dr Doerr) and Nuclear Medicine (Dr Abdel-Nabi), Veterans Administration Medical Center, Buffalo, NY, Buffalo General Hospital, and State University of New York at Buffalo; and Hybritech Inc, San Diego, Calif (Dr Merchant).

Footnotes
Accepted for publication October 14, 1989.

Read before the annual meeting of the Society of Surgical Oncology, San Francisco, Calif, May 24, 1989.

Reprint requests to Buffalo General Hospital, 100 High St, Buffalo, NY 14203 (Dr Doerr).

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