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  Vol. 125 No. 2, February 1990 TABLE OF CONTENTS
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  PAPERS READ BEFORE THE ANNUAL MEETING OF THE SOCIETY OF SURGICAL ONCOLOGY, SAN FRANCISCO, CALIF, MAY 21 TO MAY 24, 1989-PART I
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The Genetic Bases of Cancer

Lucy Wortham James Lecture

Robert A. Weinberg, PhD

Arch Surg. 1990;125(2):257-260.


Abstract

• The past three decades have witnessed enormous progress made in our understanding of the pathogenesis of cancer. Research results of the previous decades had indicated that a variety of agents, the carcinogens, could induce cancer in experimental animals. By extension, similarly acting agents were presumed to intervene in human cancer. Beyond this, the precise nature of the pathogenetic mechanisms underlying human malignancies remained obscure. In these last decades, the origins of cancer have been uncovered: specific genes and biochemical mechanisms are now known to drive the process of neoplasia.

(Arch Surg. 1990;125:257-260)



Author Affiliations

From the Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge.


Footnotes

Accepted for publication August 28, 1989.

Read before the annual meeting of the Society of Surgical Oncology, San Francisco, Calif, May 22, 1989.

Reprint requests to the Whitehead Institute of Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142 (Dr Weinberg).



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