This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Richard B. Hostetter, MD; Debora E. Campbell; Kefung Chi, MD; Susan Kerckhoff; Karen R. Cleary, MD; Steve Ullrich, PhD; Peter Thomas, PhD; J. Milburn Jessup, MD

Arch Surg. 1990;125(3):300-304.

Abstract
• Patients with human colorectal carcinoma have a poor prognosis when serum carcinoembryonic antigen level exceeds 5 ng/mL. The hypothesis that carcinoembryonic antigen enhances metastasis by promoting the attachment of tumor cells to Kupffer cells and hepatocytes was tested in an experimental metastasis model in which colorectal carcinoma cells were injected into the spleens of BALB/c athymic nude mice and liver colonies counted 5 weeks later. Pretreatment with systemic injections of carcinoembryonic antigen significantly increased the metastatic potential of a poorly metastatic colorectal carcinoma cell line KM-12c, but did not induce the nonmetastatic colorectal carcinoma cell line HC 2998 to produce metastases, nor did carcinoembryonic antigen make the highly metastatic colorectal carcinoma cell line mHC 1410 more metastatic. Carcinoembryonic antigen did not stimulate proliferation of colorectal carcinoma but appeared to be a cofactor for metastasis possibly as an adhesion factor.

(Arch Surg. 1990;125:300-304)

Author Affiliations
From the Departments of Surgery (Drs Hostetter, Chi, and Jessup, and Ms Campbell and Kerckhoff), Pathology (Dr Cleary), and Immunology (Dr Ullrich), The University of Texas M. D. Anderson Cancer Center, Houston, and the Department of Surgery, Harvard Medical School, New England Deaconess Hospital, Boston, Mass (Dr Thomas).

Footnotes
Accepted for publication December 6, 1989.

Read before the annual meeting of the Society of Surgical Oncology, San Francisco, Calif, May 22, 1989.

Reprint requests to Department of Surgery, New England Deaconess Hospital, Suite 3 A, 110 Francis St, Boston, MA 02215 (Dr Jessup).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Inhibition of Sialic Acid Incorporation Prevents Hepatic Metastases
Wagner et al.
Arch Surg 1990;125:351-354.
ABSTRACT