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Morbidity and Mortality From This Combined Treatment Modality for Unresectable Intra-abdominal Carcinomas

Thomas A. Colacchio, MD; Christopher Coughlin, MD; James Taylor, MD; Evan Douple, PhD; Thomas Ryan, MS; Robert W. Crichlow, MD

Arch Surg. 1990;125(3):370-375.

Abstract
• This is a report of a phase I trial of intraoperative radiation therapy in combination with intraoperative hyperthermia for the treatment of locally advanced, unresectable intra-abdominal carcinomas. Using an ultrasound transducer system specifically designed for intraoperative applications, 19 patients have been successfully treated, demonstrating the feasibility of this combination modality. The morbidity (58%) and mortality (11%) rates reported in this series are comparable to rates reported in series of similar patients receiving intraoperative radiation therapy alone. There is still a great need for considerable technological development to enable the use of intraoperative hyperthermia to treat large, complexly shaped intra-abdominal tumors, and phase II and III trials of this combination treatment modality should be performed.

(Arch Surg. 1990;125:370-375)

Author Affiliations
From the Department of Surgery, Dartmouth Medical School, Hanover, NH.

Footnotes
Accepted for publication December 6, 1989.

Read before the annual meeting of the Society of Surgical Oncology, San Francisco, Calif, May 24, 1989.

Reprint requests to Dartmouth Medical School, Hanover, NH 03755 (Dr Colacchio).

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