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Roderick A. Barke, MD; David L. Dunn, MD, PhD; Agustin Dalmasso, MD; Melody O'Connor Allen, MD; Edward W. Humphrey, MD, PhD

Arch Surg. 1990;125(4):437-440.

Abstract
• In a common bile duct contamination model, we studied the effect of Streptococcus faecalis compared with Escherichia coliin sheep with chronic lymph fistulas to investigate the role of enterococcus in acute lung injury and acute sepsis. Early pulmonary hypertension in the E coli group was not expressed in the S faecalis group, probably due to a failure of S faecalis to illicit a thromboxane A₂ response. In the late period, E coli was associated with significantly greater lung microvascular damage compared with S faecalis. The lack of difference between groups with respect to complement activation suggests the action of chemotactic factors, in addition to complement, mediating granulocyte aggregation, and neutropenia. In this model, S faecalis demonstrated limited pathogenicity as expressed in lung microvascular injury compared with E coli.

(Arch Surg. 1990;125:437-440)

Author Affiliations
From the Department of Surgery, Pathology, and Laboratory Medicine, University of Minnesota and Veterans Administration Medical Center, Minneapolis.

Footnotes
Accepted for publication December 17, 1989.

Read before the 13th Annual Meeting of the Association of Veterans Administration Surgeons, San Antonio, Tex, May 4, 1989.

Reprint requests to Department of Surgery (122), Minneapolis Veterans Administration Medical Center, 1 Veterans Dr, Minneapolis, MN 55417 (Dr Barke).

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