This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Use in Gram-negative Infection After Shock

Mark A. Malangoni, MD; David H. Livingston, MD; Gerald Sonnenfeld, PhD; Hiram C. Polk, Jr, MD

Arch Surg. 1990;125(4):444-446.

Abstract
• Shock increases the propensity to develop infection after injury or operation. This study evaluated the effect of cefoxitin, interferon gamma (INF-), and tumor necrosis factor alpha (TNF-) on the development of a polymicrobial soft-tissue infection. After sham operation or hemorrhagic shock and resuscitation, Sprague-Dawley rats were inoculated with 1 x 10⁸ Escherichia coli and 1 x 10⁹ Bacteroides fragilis in a 5% fecal suspension. Animals received either no treatment, cefoxitin, recombinant rat INF-, recombinant human TNF-, or cefoxitin/cytokine combinations. Cefoxitin reduced abscess size by 57% in animals without shock but only by 26% after shock. Although neither INF- nor TNF- alone had a salutary effect when given with cefoxitin in animals after shock, INF- and TNF- reduced abscess size by 50% and 55%, respectively. These results suggest that INF- and TNF- may be useful to reduce the severity of mixed gram-negative infections after shock with bacterial contamination.

(Arch Surg. 1990;125:444-446)

Author Affiliations
From the Departments of Surgery (Drs Malangoni, Livingston, and Polk) and Microbiology and Immunology (Dr Sonnenfeld), University of Louisville (Ky) and Louisville Veterans Administration Medical Center.

Footnotes
Accepted for publication August 14, 1989.

Read before the 13th Annual Meeting of the Association of Veterans Administration Surgeons, San Antonio, Tex, May 4, 1989.

Reprint requests to Department of Surgery, University of Louisville, 550 S Jackson St, Louisville, KY 40292 (Dr Malangoni).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Anti--Tumor Necrosis Factor Antibody Reduces Mortality in the Presence of Antibiotic-Induced Tumor Necrosis Factor Release
Sawyer et al.
Arch Surg 1993;128:73-78.
ABSTRACT