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Antonio Carlos Campos, MD, MS; Albert Oler, MD, PhD; Michael M. Meguid, MD, PhD; Ting-Yuan Chen, MD

Arch Surg. 1990;125(4):447-450.

Abstract
• We sought to determine whether an excess in energy intake as total parenteral nutrition would result in liver biochemical and histological changes in the presence of a functional gastrointestinal tract. Three groups of rats were given amounts of total parenteral nutrition that provided either 25% (total parenteral nutrition-25), 100% (total parenteral nutrition-100), or 200% (total parenteral nutrition-200) of a rat's energy requirements. Rat chow and water were available ad libitum. Food intake decreased in proportion to the amount of total parenteral nutrition infused; it ceased with total parenteral nutrition-200. Liver glycogen and triglyceride concentrations were higher with high energy intake (total parenteral nutrition-100 and total parenteral nutrition-200), while total liver nitrogen concentrations remained unchanged. No cholestasis, inflammation, or fibrosis was seen histologically. Fatty vacuoles were increased with total parenteral nutrition (more so with total parenteral nutrition-200) but a prompt return to normal liver features was observed after cessation of total parenteral nutrition and the resumption of normal food intake.

(Arch Surg. 1990;125:447-450)

Author Affiliations
From the Surgical Metabolism and Nutrition Laboratory, the Department of Surgery (Drs Campos, Meguid, and Chen), and the Department of Pathology (Dr Oler), University Hospital, State University of New York-Health Science Center, Syracuse.

Footnotes
Accepted for publication November 2, 1989.

Read before the 13th Annual Meeting of the Association of Veterans Administration Surgeons, San Antonio, Tex, May 4, 1989.

Reprint requests to the Surgical Metabolism and Nutrition Laboratory, the Department of Surgery, University Hospital, SUNY Health Science Center, 750 E Adams St, Syracuse, NY 13210 (Dr Meguid).

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