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Is There a Circulating Proteolysis-Inducing Factor During Sepsis?
Per-Olof Hasselgren, MD, PhD;
J. Howard James, PhD;
Daniel W. Benson, MD;
Shujun Li, MD;
Josef E. Fischer, MD
Arch Surg. 1990;125(4):510-514.
Abstract
• Muscles from fed or 72-hour fasted rats were incubated in the presence of plasma from septic rats, recombinant interleukin 1 (rIL-1), or recombinant tumor necrosis factor (rTNF), and breakdown of total and myofibrillar protein was assessed by determining release of tyrosine and 3-methylhistidine, respectively. Septic plasma stimulated total protein breakdown in muscles from 72-hour fasted rats by 10% to 20%, while myofibrillar protein breakdown was not affected. When septic plasma was added to muscles from fed rats, neither tyrosine nor 3-methylhistidine release was altered. Various concentrations of recombinant interleukin 1 or recombinant tumor necrosis factor did not affect total or myofibrillar protein breakdown. Since septic plasma did not stimulate myofibrillar protein breakdown, the role of a circulating factor for muscle proteolysis during sepsis remains unclear.
(Arch Surg. 1990;125:510-514)
Author Affiliations
From the Department of Surgery, University of Cincinnati (Ohio) Medical Center.
Footnotes
Accepted for publication January 5, 1990.
Reprint requests to Department of Surgery, University of Cincinnati Medical Center, 231 Bethesda Ave, Cincinnati, OH 45267-0558 (Dr Fischer).
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