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An Index of Prognosis for Hepatic Resection

Yoshiharu Sakai, MD; Akira Tanaka, MD; Iwao Ikai, MD; Atsuhiko Maki, MD; Takashi Takayasu, MD; Yoshio Yamaoka, MD; Kazue Ozawa, MD; Yutaka Orii, PhD

Arch Surg. 1990;125(5):632-635.

Abstract
• Cytochrome c oxidase activity, measured as V_max (nanomoles of cytochrome c oxidized per second per milligram of protein) and Michaelis constant (K_m) (micromoles per liter),was measured spectrophotometrically in human liver specimens obtained by needle biopsy from 43 patients. In 16 normal livers, the V_max and K_m values ranged from 1.26 to 2.25 nmol/s per milligram of protein and from 2.78 to 3.95 µmol/L, respectively. In 27 patients with liver cirrhosis or chronic hepatitis, these values ranged from 1.60 to 3.80 nmol/s per milligram of protein and from 2.80 to 6.50 µmol/L, respectively. Patients with V_max above 2.5 nmol/s per milligram of protein or K_m above 5.0 µmol/L had a high incidence of postoperative complications even after minor hepatic resection. By contrast, even patients with liver cirrhosis or chronic hepatitis could tolerate major hepatic resection as long as their V_max and K_m values were within the normal range. These findings indicate that the cytochrome c oxidase activity in liver specimens can serve as a prognostic sign in hepatic resection even in patients with liver cirrhosis or chronic hepatitis.

(Arch Surg. 1990;125:632-635)

Author Affiliations
From the Second Department of Surgery (Drs Sakai, Tanaka, Ikai, Maki, Takayasu, Yamaoka, and Ozawa) and the Department of Public Health (Dr Orii), Faculty of Medicine, Kyoto University, Japan.

Footnotes
Accepted for publication July 8, 1989.

Reprint requests to Second Department of Surgery, Faculty of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyoku, Kyoto, 606 Japan (Dr Sakai).

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ABSTRACT