This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (10)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

J. Peter Bentley, PhD; Thomas K. Hunt, MD; Jacqueline B. Weiss, DSc; Christopher M. Taylor, PhD; Albert N. Hanson; Gordon H. Davies, MIST; Betty J. Halliday

Arch Surg. 1990;125(5):641-646.

Abstract
• Live yeast cell derivative is an alcoholic extract from yeast (Saccharomyces cerevisiae) that has previously been shown by three groups of workers to stimulate wound healing. Live yeast cell derivative is a complex mixture, and it was not known which of its many components was responsible for the biological activity. This study describes the separation and analysis of the major components, one of which is a peptide fraction that stimulates wound healing. The fraction consists of a mixture of peptides from 6000 to 17000 d. It causes angiogenesis in a chick embryo yolk sac membrane assay and in a rabbit cornea assay, and it dramatically stimulates wound healing in the "Schilling/Hunt" wire mesh cylinder model at concentrations 25-fold lower than those required for the intact live yeast cell derivative.

(Arch Surg. 1990;125:641-646)

Author Affiliations
From the Department of Biochemistry, Oregon Health Sciences University School of Medicine, Portland (Dr Bentley and Messrs Hanson and Davies), the Department of Surgery, University of California, San Francisco (Dr Hunt and Ms Halliday), and the Wolfson Angiogenesis Unit, University of Manchester, Hope Hospital, Salford, England (Drs Weiss and Taylor).

Footnotes
Accepted for publication October 25, 1989.

Reprint requests to Department of Biochemistry, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, L333A, Portland, OR 97201 (Dr Bentley).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?