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The Influence of Tumor Size

Timothy J. Eberlein, MD; James L. Connolly, MD; Stuart J. Schnitt, MD; Abram Recht, MD; Robert T. Osteen, MD; Jay R. Harris, MD

Arch Surg. 1990;125(6):771-777.

Abstract
• Size of tumor has not been established as a predictor of tumor recurrence in the breast following conservative surgery and radiation therapy. We analyzed 783 patients with infiltrating carcinoma treated with simple excision and radiation therapy. Median follow-up was 91 months. Median age at diagnosis was 50 years. There was a 13% recurrence among patients with T1 lesions compared with a 12% recurrence among patients with T2 tumors. Size did not predict for local recurrence when the tumor was analyzed by 1-cm increments and whether the tumor was estrogen receptor protein positive or estrogen receptor protein negative. Patients with an extensive intraductal component had a significantly higher local recurrence rate for every tumor size compared with patients with extensive intraductal component–negative tumors. We concluded that size did not predict local recurrence.

(Arch Surg. 1990;125:771-777)

Author Affiliations
From the Division of Surgical Oncology, Department of Surgery, Brigham and Women's Hospital and Harvard Medical School (Drs Eberlein and Osteen); the Department of Pathology, Beth Israel Hospital and Harvard Medical School (Drs Connolly and Schnitt); and the Joint Center for Radiation Therapy, Harvard Medical School (Drs Recht and Harris), Boston, Mass.

Footnotes
Accepted for publication April 5, 1990.

Read before the 70th Annual Meeting of the New England Surgical Society, Bretton Woods, NH, September 23, 1989.

Reprint requests to Department of Surgery, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (Dr Eberlein).

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