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The Effect of Interleukin 1 on Survival in a Murine Model of Burn Wound Sepsis

Geoffrey M. Silver, MD; Richard L. Gamelli, MD; Michael O'Reilly, MS; James C. Hebert, MD

Arch Surg. 1990;125(7):922-925.

Abstract
• We examined the effects of human recombinant interleukin 1 (IL-1 ) in a murine model of burn wound sepsis. The BDF₁ male mice received a 15% burn injury, followed by burn wound inoculation with Pseudomonas aeruginosa. Improvement in survival was noted in the mice that received a single injection of 100 or 1000 ng of IL-1 in comparison with the control animals (IL-1, 100 ng vs control, 60% vs 13%; IL-1, 1000 ng vs control, 40% vs 0%). The animals that received 1 ng twice daily for 7 days had improved survival in comparison with the controls (IL-1 vs control, 70.8% vs 20.8%). The animals that received a single injection of 1000 ng after a bacterial challenge with 10⁴ P aeruginosa of IL-1 had fewer positive blood cultures at 48 hours compared with the controls (57% vs 89%). In addition, the animals that received 100 ng of IL-1 had significantly increased absolute neutrophil counts at 6, 24, and 48 hours after thermal injury and bacterial challenge with 10³ colony-forming units of P aeruginosa. The use of cytokines to modulate the host response to injury or infection may lead to additional strategies to improve the outcome following burn injury.

(Arch Surg. 1990;125:922-925)

Author Affiliations
From the Department of Surgery, University of Vermont College of Medicine, Burlington.

Footnotes
Accepted for publication April 24, 1989.

Read before the Ninth Annual Meeting of the Surgical Infection Society, Denver, Colo, April 14, 1989.

Reprint requests to Department of Surgery, University of Vermont College of Medicine, Given Building, Burlington, VT 05405 (Dr Gamelli).

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