Hydroxyethyl starch macromolecules reduce myocardial reperfusion injury
B. A. Zikria, C. Subbarao, M. C. Oz, S. J. Popilkis, R. Sachdev, P. Chauhan, H. P. Freeman and T. C. King
Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY.
We assessed the value of a fraction of hydroxyethyl starch (HES Pz) in
reducing the myocardial reperfusion injury in a canine open-chest model in
which 1 hour of left anterior descending coronary artery occlusion was
followed by 24 hours of reperfusion. Three treatment infusions (5% of blood
volume) were compared: Ringer's lactate, serum albumin, and HES Pz (70% of
the macromolecules between 100,000 and 1,000,000 d). When compared with
Ringer's lactate and albumin, HES Pz significantly reduced the ratio of
24-hour infarct size to pretreatment area at risk (3% vs 19% and 16%,
respectively) and myocardial water content (0.5% vs 3% and 1%). Potassium
content differences between injured and normal myocardium were
significantly less in the infarct regions of animals receiving HES Pz. In
the canine model, HES Pz reduced 1-hour myocardial ischemia reperfusion
injury significantly.
