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Hydroxyethyl Starch Macromolecules Reduce Myocardial Reperfusion Injury
Bashir A. Zikria, MD;
Chivukula Subbarao, MD;
Mehmet C. Oz, MD;
Sulli J. Popilkis, DVM;
Ranjit Sachdev, MD;
Prem Chauhan, MD;
Harold P. Freeman, MD;
Thomas C. King, MD
Arch Surg. 1990;125(7):930-934.
Abstract
• We assessed the value of a fraction of hydroxyethyl starch (HES PZ) in reducing the myocardial reperfusion injury in a canine open-chest model in which 1 hour of left anterior descending coronary artery occlusion was followed by 24 hours of reperfusion. Three treatment infusions (5% of blood volume) were compared: Ringer's lactate, serum albumin, and HES PZ (70% of the macromolecules between 100 000 and 1 000 000 d). When compared with Ringer's lactate and albumin, HES PZ significantly reduced the ratio of 24-hour infarct size to pretreatment area at risk (3% vs 19% and 16%, respectively) and myocardial water content (0.5% vs 3% and 1%). Potassium content differences between injured and normal myocardium were significantly less in the infarct regions of animals receiving HES PZ. In the canine model, HES PZ reduced 1-hour myocardial ischemia reperfusion injury significantly.
(Arch Surg. 1990;125:930-934)
Author Affiliations
From the Department of Surgery, College of Physicians and Surgeons, Columbia University (Drs Zikria, Oz, Popilkis, and King), and Departments of Surgery (Drs Zikria, Subbarao, and Freeman) and Pathology (Drs Sachdev and Chauhan), Harlem Hospital Medical Center, New York, NY.
Footnotes
Accepted for publication November 14, 1989.
Read in part at the American Heart Association Scientific Session, Washington, DC, November 14, 1988.
Reprint requests to Box 429, Department of Surgery, Columbia-Presbyterian Medical Center, 622 W 168th St, New York, NY 10032 (Dr Zikria).
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