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II. Effect on Response to Endotoxin

J. Paul Waymack, MD, ScD; Gabriel Fernandes, PhD; Patricia J. Cappelli; David G. Burleson, PhD; Rey F. Guzman; Arthur D. Mason, Jr, MD; Basil A. Pruitt, Jr, MD

Arch Surg. 1991;126(1):59-62.

Abstract
• The effect of blood transfusions and anesthesia on host response to endotoxin was evaluated in multiple Lewis rat models. The rats were randomized to receive A'Sogaloff Cancer Institute rat blood, pentobarbital sodium, or lactated Ringer's solution and, at either 2 or 7 days following administration of these agents, were challenged with intravenous endotoxin. Neither blood transfusions nor anesthesia altered mortality when administered 2 days before endotoxin challenge. However, blood transfusions administered 7 days before endotoxin challenge were found to prolong survival, to prevent endotoxin-induced alterations in T-lymphocyte subsets, and to decrease plasma tumor necrosis factor levels. In conclusion, blood transfusions appear to depress immune function in a beneficial manner in endotoxin shock.

(Arch Surg. 1991;126:59-62)

Author Affiliations
From the US Army Institute of Surgical Research (Drs Waymack, Burleson, Mason, and Pruitt and Mr Guzman) and the Department of Immunology, University of Texas Health Science Center (Dr Fernandes and Ms Cappelli), San Antonio, Tex.

Footnotes
Accepted for publication September 29, 1990.

Read before the Tenth Anniversary Meeting of the Surgical Infection Society, Cincinnati, Ohio, June 14, 1990.

The opinions or assertions contained herein are the private views of the authors and not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Reprint requests to US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234-5012 (Dr Waymack).

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