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Effects of Granulocyte-Macrophage Colony-Stimulating Factor in Burn Patients
MAJ William G. Cioffi, Jr, MC;
LTC David G. Burleson, PhD;
Bryan S. Jordan, MS;
LTC William K. Becker, MC;
COL William F. McManus, MC;
Arthur D. Mason, Jr, MD;
COL Basil A. Pruitt, Jr, MC
Arch Surg. 1991;126(1):74-79.
Abstract
• We studied the effects of granulocyte-macrophage colony-stimulating factor in burn patients. Serial measurements of granulocyte oxidative function were obtained in treated patients and in a group of controls matched for age and total burn size. The administration of granulocyte-macrophage colony-stimulating factor resulted in a 50% increase in mean leukocyte counts. Both groups showed significant baseline increases in granulocytic cytosolic oxidative function. Treated patients showed normal stimulated cytosolic oxidative function, which was significantly depressed compared with that of untreated patients. Myeloper-oxidase activity was increased in treated patients during the first postburn week but then declined to normal levels. Untreated patients had a significant increase in myeloperoxidase activity for the first 3 weeks following injury. Untreated patients exhibited a significant decrease in superoxide activity during the second 3 weeks following injury. Treated patients demonstrated normal superoxide activity.
(Arch Surg. 1991; 126:74-79)
Author Affiliations
USA; USA; USA; USA
From the US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Tex.
Footnotes
Accepted for publication September 29, 1990.
Read before the Tenth Anniversary Meeting of the Surgical Infection Society, Cincinnati, Ohio, June 15, 1990.
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
Reprint requests to the US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234-5012 (Dr Pruitt).
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