Effects of granulocyte-macrophage colony-stimulating factor in burn patients
W. G. Cioffi Jr, D. G. Burleson, B. S. Jordan, W. K. Becker, W. F. McManus, A. D. Mason Jr and B. A. Pruitt Jr
US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234-5012.
We studied the effects of granulocyte-macrophage colony-stimulating factor
in burn patients. Serial measurements of granulocyte oxidative function
were obtained in treated patients and in a group of controls matched for
age and total burn size. The administration of granulocyte-macrophage
colony-stimulating factor resulted in a 50% increase in mean leukocyte
counts. Both groups showed significant baseline increases in granulocytic
cytosolic oxidative function. Treated patients showed normal stimulated
cytosolic oxidative function, which was significantly depressed compared
with that of untreated patients. Myeloperoxidase activity was increased in
treated patients during the first postburn week but then declined to normal
levels. Untreated patients had a significant increase in myeloperoxidase
activity for the first 3 weeks following injury. Untreated patients
exhibited a significant decrease in superoxide activity during the second 3
weeks following injury. Treated patients demonstrated normal superoxide
activity.
