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Timothy J. Yeatman, MD; Geoffrey L. Risley, MD; Mathew E. Brunson, MD

Arch Surg. 1991;126(11):1376-1382.

Abstract
• The effects of dietary arginine on the growth of a murine colon tumor metastatic to the liver were examined in a model of advanced neoplastic disease. Tumor growth was influenced by arginine both in vivo and in vitro. An arginine-supplemented diet stimulated tumor growth by 55% compared with controls. Conversely, an argininedepleted diet inhibited tumor growth by 78% compared with controls. In vitro culture of both murine and human colon tumor cells confirmed that arginine was necessary for cell growth. Flow-cytometric analysis using propidium iodide and bromodeoxyuridine suggested that colon tumor cells cultured without arginine enter a quiescent S phase and depend on arginine for further growth and cell cycle progression. The potential roles for selective dietary arginine modulation in patients with cancer with advanced disease are discussed.

(Arch Surg. 1991;126:1376-1382)

Author Affiliations
From the Department of Surgery, University of Texas, MD Anderson Cancer Center (Dr Yeatman); the Department of Surgery, University of North Carolina, Chapel Hill (Dr Risley); and the Department of Surgery, University of Florida College of Medicine, Gainesville (Dr Brunson).

Footnotes
Accepted for publication August 3, 1991.

Presented at the 44th Annual Cancer Symposium of the Society of Surgical Oncology, Orlando, Fla, March 26, 1991.

Reprint requests to the Department of Surgery, Box 106, University of Texas, MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77036 (Dr Yeatman).

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