Treatment of abdominal malignant neoplasms using regional chemotherapy with hemofiltration
J. H. Muchmore, E. T. Krementz, R. D. Carter, J. E. Preslan and W. J. George
Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112.
The regional delivery of high-dose chemotherapy for malignant neoplasms of
the limb with the isolated regional perfusion technique was first described
in the late 1950s. Recently, the use of concomitant hemofiltration for
rapid systemic drug removal permits the use of higher regional drug levels
in treating patients with advanced abdominal malignant neoplasms without
complete vascular isolation. Twenty-five patients successfully underwent 42
treatments of high-dose intra-arterial chemotherapy with concomitant
hemofiltration at Tulane University Medical Center Hospital, New Orleans,
La, from 1989 through 1990. One patient (4%) achieved a complete response.
Two patients (8%) had partial responses following high-dose intra-arterial
chemotherapy with concomitant hemofiltration and their residual disease was
resected for cure. Seven patients (28%) achieved a partial response, 11
(44%) had stable disease, and four (16%) had progression of disease.
