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Effect of Dietary Fish Oil on Plasma Thromboxane B2 and 6-Keto-prostaglandin F1 Levels in Septic Rats

Farid F. Muakkassa, MD; Mark J. Koruda, MD; Fuad M. Ramadan, MD; Masato Kawakami, MD; Anthony A. Meyer, MD

Arch Surg. 1991;126(2):179-182.

Abstract
• Increased mortality from sepsis is associated with high levels of thromboxane B₂ (TXB₂) and 6-keto-prostaglandin F₁ (PGF₁). Linoleic acid, an n-6 essential fatty acid, is the usual precursor of TXB₂ and PGF₁, while fish oil is rich in n-3 essential fatty acid, the precursor of less active moieties. Rats were fed chow, an essential fatty acid–deficient diet, or an essential fatty acid–deficient diet supplemented with linoleic acid or fish oil for 2 weeks. The animals then underwent a sham operation or cecal ligation and puncture to induce sepsis. Six hours later, blood was obtained for analysis. The chow and linoleic acid diets produced significant (twofold to fivefold) increases in levels of both TXB₂ and PGF₁ after sepsis. The essential fatty acid–deficient diet and fish oil diet protected against increases in levels of TXB₂ or PGF₁ during sepsis. Dietary restriction of linoleic acid or fish oil supplementation may play an important role in altering the inflammatory mediator response to sepsis.

(Arch Surg. 1991;126:179-182)

Author Affiliations
From the Department of Surgery, the University of North Carolina at Chapel Hill. Dr Muakkassa is now with the University of Mississippi Medical Center, Jackson, and Dr Ramadan is now with the University of Pittsburgh (Pa).

Footnotes
Accepted for publication September 30, 1990.

Read before the Tenth Anniversary Meeting of the Surgical Infection Society, Cincinnati, Ohio, June 14, 1990.

Reprint requests to the Department of Surgery, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216-4505 (Dr Muakkassa).

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