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Leopoldo Sánchez-Cantú, MD; Harold N. Rode, PhD; Theodore J. Yun; Nicolas V. Christou, MD, PhD

Arch Surg. 1991;126(2):231-235.

Abstract
• Lethality and tumor necrosis factor production induced by different types of lipopolysaccharide were studied in naive (non-primed) rats during the late phase of endotoxin tolerance. The correlation with antilipopolysaccharide antibodies was also analyzed. No correlation was found between tumor necrosis factor levels and lipopolysaccharide-induced mortality in naive animals. Low-toxicity lipopolysaccharide preparations induced levels of tumor necrosis factor similar to those induced with more toxic types of lipopolysaccharide. Late tolerance was associated with progressively lower levels of lipopolysaccharide-induced tumor necrosis factor and increasing titers of antilipopolysaccharide antibodies after repeated injections of homologous lipopolysaccharide. During late entodoxin tolerance, a direct correlation between the lipopolysaccharide dose and peak tumor necrosis factor serum levels was found. We conclude that since tumor necrosis factor serum levels do not correlate with mortality, tumor necrosis factor alone cannot explain the lethal effect of lipopolysaccharide.

(Arch Surg. 1991;126:231-235)

Author Affiliations
From the Department of Surgery, McGill University, Montreal, Quebec. Dr Sánchez-Cantú is currently with the Department of Surgery, Hospital Infantil de México, Mexico City. Dr Rode is currently with the Immunology Section, Bureau of Biologics, HWC, Ottawa, Ontario.

Footnotes
Accepted for publication October 28, 1990.

Read before the 10th Anniversary Meeting of the Surgical Infection Society, Cincinnati, Ohio, June 15, 1990.

Reprint requests to the Royal Victoria Hospital, Department of Surgery, Room S10.30, 687 Pine Ave W, Montreal, Quebec, Canada H3A 1A1 (Dr Christou).

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