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Lorenzo Dominioni, MD; Renzo Dionigi, MD; Marco Zanello, MD; Maurizio Chiaranda, MD; Roberto Dionigi, MD; Annamaria Acquarolo, MD; Andrea Ballabio, MD; Chiara Sguotti, MD

Arch Surg. 1991;126(2):236-240.

Abstract
• Sixty-two consecutive septic surgical patients receiving standard multimodal intensive care unit treatment who developed a sepsis score of 20 or greater (day 0) were randomized to receive 0.4 g/kg of either intravenous IgG (29 patients) or human albumin (controls; 33 patients), repeated on days +1 and + 5, in a prospective, double-blind, multicenter study. The two groups were similar in age, initial sepsis scores, and acute physiology and chronic health evaluation II score. A significantly lower mortality was recorded in the IgG-treated group (38%) than in controls (67%). Septic shock was the cause of death in 7% of IgG-treated patients and in 33% of controls. The results of this study indicate that high-dose IgG improves survival and decreases death from septic shock in surgical patients with a sepsis score of 20 or greater.

(Arch Surg. 1991;126:236-240)

Author Affiliations
From the Department of Surgery and Institute of Anesthesiology, University of Pavia, Varese, Italy (Drs Dominioni, Renzo Dionigi, Chiaranda, Roberto Dionigi, Ballabio, and Sguotti); Institute of Anesthesiology, University of Bologna (Italy) (Dr Zanello); and Institute of Anesthesiology, University of Brescia (Italy) (Dr Acquarolo).

Footnotes
Accepted for publication October 14, 1990.

Read before the Tenth Anniversary Meeting of the Surgical Infection Society, Cincinnati, Ohio, June 15, 1990.

Reprint requests to Department of Surgery, University of Pavia, Ospedale Multizonale, 21100 Varese, Italy (Dr Dominioni).

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