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Douglas L. Vander Woude, MD; Paul D. Wagner; Suyu Shu, PhD; Alfred E. Chang, MD

Arch Surg. 1991;126(3):307-313.

Abstract
• Tumor-draining lymph node cells from mice bearing the methylcholanthrene-induced MCA106 tumors can be sensitized in vitro to acquire antitumor reactivity. We examined the effect of interferon alfa on the function of cells that underwent in vitro sensitization in adoptive immunotherapy. Interferon alfa increased the antitumor reactivity of in vitro sensitized cells in the treatment of MCA 106 pulmonary metastases. This effect was evident in irradiated mice, indicating that a host response to the interferon alfa was not required. Interferon alfa treatment increased class I major histocompatibility complex antigen expression on tumor cells and increased their susceptibility to lysis by in vitro sensitized cells. These results suggest that interferon alfa enhancement of adoptive immunotherapy was mediated by its effect on tumor cells. Interferon alfa may be a useful adjunct to the adoptive immunotherapy of human cancer.

(Arch Surg. 1991;126:307-313)

Author Affiliations
From the Division of Surgical Oncology, University of Michigan, Ann Arbor.

Footnotes
Accepted for publication November 17, 1990.

Read before the 43rd Annual Cancer Symposium of the Society of Surgical Oncology, Washington, DC, May 20, 1990.

Reprint requests to the Division of Surgical Oncology, University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109 (Dr Chang).

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