Prognostic factors in primary retroperitoneal soft-tissue sarcomas

R. G. Bevilacqua, A. Rogatko, S. I. Hajdu and M. F. Brennan
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.

We analyzed independent treatment variables (age, sex, signs and symptoms, site, size, histopathologic findings, grade, and clinical presentation) and treatment-dependent variables (resectability, type of operation, surgical margins, surgical boundaries, microscopic margins, adjuvant radiotherapy, and adjuvant chemotherapy) in 80 patients with primary retroperitoneal soft-tissue sarcomas admitted from 1982 through 1988. Both univariate and multivariate analysis of survival and disease-free survival were performed. The major factor in survival outcome was the ability to completely resect the lesion. When the 62 patients who underwent complete resection were examined, the only independent prognostic factor for both survival and disease-free survival was grade. We conclude that completeness of resection and grade of the lesion are primary determinants of survival. Once all tumor is macroscopically removed, no advantage could be demonstrated by more extensive surgical resection or current adjuvant therapy.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Use of Tissue Expanders and Pre-operative External Beam Radiotherapy in the Treatment of Retroperitoneal Sarcoma
White et al.
Ann. Surg. Oncol. 2007;14:583-590.
ABSTRACT | FULL TEXT  

Long-Term Results of Two Prospective Trials of Preoperative External Beam Radiotherapy for Localized Intermediate- or High-Grade Retroperitoneal Soft Tissue Sarcoma
Pawlik et al.
Ann. Surg. Oncol. 2006;13:508-517.
ABSTRACT | FULL TEXT  

Soft-Tissue Sarcomas of the Chest Wall: Prognostic Factors
Gross et al.
Chest 2005;127:902-908.
ABSTRACT | FULL TEXT  

Soft Tissue Sarcomas of Adults: State of the Translational Science
Borden et al.
Clin. Cancer Res. 2003;9:1941-1956.
ABSTRACT | FULL TEXT  

Retroperitoneal Sarcomas: Grade and Survival
Ferrario and Karakousis
Arch Surg 2003;138:248-251.
ABSTRACT | FULL TEXT  

Response to Neoadjuvant Chemotherapy Combined With Regional Hyperthermia Predicts Long-Term Survival for Adult Patients With Retroperitoneal and Visceral High-Risk Soft Tissue Sarcomas
Wendtner et al.
JCO 2002;20:3156-3164.
ABSTRACT | FULL TEXT  

Influence of Biologic Factors and Anatomic Site in Completely Resected Liposarcoma
Linehan et al.
JCO 2000;18:1637-1643.
ABSTRACT | FULL TEXT  

CT of Recurrent Retroperitoneal Sarcomas
Gupta et al.
Am. J. Roentgenol. 2000;174:1025-1030.
ABSTRACT | FULL TEXT  

Vascular Reconstruction and Major Resection for Malignancy
Bianchi et al.
Arch Surg 1999;134:851-855.
ABSTRACT | FULL TEXT  

Importance of Surgical Resection in the Successful Management of Soft Tissue Sarcoma
Flugstad et al.
Arch Surg 1999;134:856-862.
ABSTRACT | FULL TEXT