You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


Advertisement

ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | RSS | Access Rights | Sign In


  Vol. 126 No. 4, April 1991 TABLE OF CONTENTS
  Online Only
 •  Online First Table of
Contents
  PAPERS READ BEFORE THE 43RD ANNUAL CANCER SYMPOSIUM OF THE SOCIETY OF SURGICAL ONCOLOGY, WASHINGTON, DC, MAY 19 TO 22, 1990-PAR T II
 •Online Features
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (43)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Delicious Add to Digg Add to Facebook Add to Reddit Add to Technorati Add to Twitter What's this?

Effect of Morphine on Growth of Metastatic Colon Cancer In Vivo

Mark P. Yeager, MD; Thomas A. Colacchio, MD

Arch Surg. 1991;126(4):454-456.


Abstract



• Control of colon cancer depends, in part, on intact immune defense mechanisms. Since opiates are known to affect some components of immune function, this study was conducted to determine the effect of high-dose subcutaneous morphine sulfate and of low-dose intrathecal morphine on the postoperative growth of metastatic colon cancer. Five groups of 15 Fischer 344 rats were given intraportal injections of colon cancer cells as follows: group 1, control; group 2, daily subcutaneous injections of 20-mg/kg morphine the day before and for 2 days after colon cancer cell inoculation; group 3, daily subcutaneous injections of saline; group 4, daily intrathecal injections of 20 µg of morphine; and group 5, daily intrathecal injections of saline. There was a significant decrease in the hepatic tumor burden in group 2 compared with groups 1 and 3 and a significant increase in the hepatic tumor burden in groups 4 and 5 compared with group 1. This study demonstrates that intermittent injections of a narcotic may decrease the growth of tumor cells that gain access to the circulation during a surgical procedure. In addition, the results support the concept that tumor cells entering the circulation during a vulnerable period of postoperative immunosuppression are more likely to survive as metastatic tumor.

(Arch Surg. 1991;126:454-456)



Author Affiliations



From the Departments of Anesthesiology and Medicine (Dr Yeager) and Surgery (Dr Colacchio), Dartmouth-Hitchcock Medical Center, Hanover, NH.


Footnotes



Accepted for publication January 12, 1991.

Read before the 43rd Annual Cancer Symposium of the Society of Surgical Oncology, Washington, DC, May 20, 1990.

Reprint requests to Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, 2 Maynard St, Hanover, NH 03756 (Dr Yearger).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Risks and benefits of thoracic epidural anaesthesia
Freise and Van Aken
Br J Anaesth 2011;107:859-868.
ABSTRACT | FULL TEXT  

Opioids and the immune system
Sacerdote
Palliat Med 2006;20:9-15.
ABSTRACT  

Opioids As Modulators of Cell Death and Survival--Unraveling Mechanisms and Revealing New Indications
Tegeder and Geisslinger
Pharmacol. Rev. 2004;56:351-369.
ABSTRACT | FULL TEXT  

G Protein-independent G1 Cell Cycle Block and Apoptosis with Morphine in Adenocarcinoma Cells: Involvement of p53 Phosphorylation
Tegeder et al.
Cancer Res. 2003;63:1846-1852.
ABSTRACT | FULL TEXT  

The Effects of Tramadol and Morphine on Immune Responses and Pain After Surgery in Cancer Patients
Sacerdote et al.
Anesth. Analg. 2000;90:1411-1414.
ABSTRACT | FULL TEXT  

Clinical research on heroin in cancer pain control
Baumrucker
AM J HOSP PALLIAT CARE 2000;17:8-9.
 





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | PHYSICIAN JOBS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1991 American Medical Association. All Rights Reserved.