 |
|
Does Selective Decontamination of the Gastrointestinal Tract Prevent Multiple Organ Failure?An Experimental Study
R. Jan A. Goris, MD;
Ignas P. T. van Bebber, MD;
Roland M. H. Mollen, MD;
Johan P. Koopman, PhD
Arch Surg. 1991;126(5):561-565.
Abstract
• Gut bacteria have been incriminated as causing or contributing to generalized sepsis with multiple organ failure in severely ill patients, and selective decontamination of the gastrointestinal tract of Enterobacteriaceae has been claimed to decrease septic complications in these patients. We studied the effects of selective decontamination of the gastrointestinal tract on survival and organ function in an experimental model of sepsis with multiple organ failure. Wistar rats were inoculated intraperitoneally with zymosan and randomized into control or treatment groups (trimethoprim or streptomycin sulfate). Selective decontamination effectively prevented bacterial translocation of Enterobacteriaceae. However, only early mortality was decreased, and only so in the streptomycin-treated rats. Selective decontamination did not result in a significantly better condition of the surviving animals on day 12.
(Arch Surg. 1991;126:561-565)
Author Affiliations
From the Department of General Surgery (Drs Goris, van Bebber, and Mollen) and the Central Animal Laboratory (Dr Koopman), University Hospital St Radboud, Nijmegen, the Netherlands.
Footnotes
Accepted for publication July 21, 1990.
Reprint requests to Department of General Surgery, University Hospital St Radboud, PO Box 9101, 6500 HB Nijmegen, the Netherlands (Dr Go ris).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Reduction of the intestinal endotoxin pool by three different SDD regimens in human volunteers
van Saene et al.
Innate Immunity 1996;3:337-343.
ABSTRACT
Prognosis and Treatment of Peritonitis: Do We Need New Scoring Systems?
Koperna and Schulz
Arch Surg 1996;131:180-186.
ABSTRACT
|
