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Roland Andersson, MD, PhD; Claes Schlén, MD, PhD; Karl-Göran Tranberg, MD, PhD

Arch Surg. 1991;126(6):773-777.

Abstract
• The effect of intraperitoneal bile on growth, peritoneal absorption, and clearance of Escherichia coli was determined in E coli peritonitis in the rat. In E coli peritonitis, intraperitoneal bacterial counts gradually decreased, whereas they increased (after 2 hours) with subsequent development of bacteremia in E coli plus bile peritonitis. After an intraperitoneal injection of labeled bacteria, blood radioactivity was only initially lower in E coli plus bile peritonitis compared with E coli peritonitis. Clearance from blood was lower in E coli plus bile peritonitis than in E coli peritonitis. Organ localization was similar in E coli peritonitis and E coli plus bile peritonitis with decreased splenic, increased pulmonary, and unchanged hepatic uptakes compared with controls. Impaired peritoneal absorption of bacteria, together with impaired local host defense, is likely to enhance the noxious effect of bile in E coli peritonitis.

(Arch Surg. 1991;126:773-777)

Author Affiliations
From the Departments of Surgery (Drs Andersson and Tranberg) and Medical Microbiology (Dr Schalén), Lund (Sweden) University.

Footnotes
Accepted for publication October 13, 1990.

Reprint requests to the Department of Surgery, Lund University, S-221 85 Lund, Sweden (Dr Andersson).

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